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Soft tissue sarcomas are a broad category of tumors that can develop over the chest, back, side, legs, and facial tissues of your pet. The clinical signs depend on where the tumor is located and the tissues that are affected. Often, pets have a noticeable mass that is growing in size. One of the biggest concerns with soft tissue sarcomas is their ability to invade the local surrounding tissues. The most commonly pursued treatment is surgery. Chemotherapy is not usually pursued as a primary treatment unless surgery or radiation are not options for your pet based on the tumor size or location.
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Squamous cell carcinoma (SCC) is a tumor of the cells that make up the contact or upper layer of the skin. UV light exposure has been described as a developmental factor in people and appears to be associated with its development in cats. Areas affected include the ear tips, skin, toes, or peri-ocular region. Fine needle aspiration or biopsy may be performed for diagnosis. The metastatic rate does not appear overly clear, though staging is always recommended. SCC of the toe can occur as a primary tumor or may have spread from the lung (lung-digit syndrome). Surgery is almost always recommended in any case of SCC; the role of chemotherapy is controversial. Radiation therapy has an excellent response rate in cats with the SCC affecting the nasal planum and may give long-term tumor control.
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Squamous cell carcinoma is a tumor of the cells that make up the contact or upper layer of the skin. UV light exposure has been described as a developmental factor in people, though it is still in question as to the role for dogs. Several breeds are known to be predisposed to this type of cancer. About 30% of dogs with the digital form of the disease will have evidence of spread. Regardless of the location, surgery is typically the treatment of choice, and staging is usually recommended prior to any surgery.
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Stomach tumors are uncommon in dogs and cats. There are many kinds, including leiomyosarcomas, lymphomas, adenocarcinomas, mast cell tumors, fibrosarcomas, plasmacytomas, gastrointestinal stromal tumors (GISTs), and carcinoids (all malignant); and leiomyomas, adenomatous polyps, and adenomas (benign). Most tumors are malignant. Stomach tumors are more prevalent in older animals, males, and certain breeds. The signs of stomach tumors include chronic vomiting, inappetence, lethargy, and weight loss. Sometimes tumor ulceration will cause anemia. Paraneoplastic syndromes are possible with the muscle tumors. Stomach tumors may be diagnosed with imaging, endoscopy, or surgery, with a biopsy. Treatment may involve surgery, chemotherapy, or radiation therapy.
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Skin gland, hair follicle, and sebaceous gland tumors are often benign. Matrical carcinoma and sebaceous gland adenocarcinoma are rare and more aggressive forms of the disease. Regardless of the type (sweat, hair, or sebaceous) diagnosis is made by fine needle aspiration, biopsy, and/or surgical removal and histopathology. Further treatment is reviewed.
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Testicular tumors are generally not aggressive and have a low metastatic rate. Pets with undescended testicles (cryptorchid) are predisposed to the development of certain testicular tumors. Hyperestogenism is possible with Sertoli cell tumors. In any cryptorchid pet, removal of both testicles should be pursued. Intraabdominal tumors in cryptorchid pets may cause lethargy, decreased appetite, and fever. Standard staging is recommended in all cases, including a rectal exam. Surgery is typically the treatment of choice and may be combined with radiation therapy or chemotherapy if metastasis is evident.
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Thyroid tumors can be benign or malignant and functional or non-functional. In dogs, they are usually malignant and non-functional, whereas in cats, they are usually benign and functional. A swelling in the neck may be the only sign in a dog; however, a change in bark, coughing, difficulty swallowing, facial swelling, rapid breathing, breathlessness, weight loss, and a loss of appetite are possible. In cats, the signs are related to excess thyroid hormone production (hyperthyroidism). Thyroid tumors are diagnosed with a physical examination, bloodwork, various forms of diagnostic imaging, and in dogs, a tissue biopsy. In dogs, staging is required to determine the presence of spread. A variety of treatment options are available.
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Transmissible venereal tumors (TVTs), often found in genital areas, are spread through contact with other dogs, most often sexual contact. The tumors are usually cauliflower-like in appearance. Diagnosis and treatment is discussed.
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Tumors of the urinary tract may present anywhere from the kidneys to the tip of the urethra. Tumors of the bladder are most common in the dog whereas tumors involving the kidneys are more prevalent in cats. Unfortunately, many tumors of the urinary tract are malignant and treatment options may be limited. Surgery is possible in select cases. Medical treatment may be beneficial in cases where surgery is not possible.
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Uterine tumors are quite rare in North American pets, mainly due to routine spaying practices. Several types of tumors can arise from the tissues of the uterus. This handout discusses uterine tumors in dogs and cats. The various types of these tumors, along with the clinical signs, diagnosis, treatment, and prevention of this condition are outlined.